lower brain stem function development in infants

The results suggest poor myelination and synaptic function of the brainstem in infants with bronchopulmonary dysplasia, resulting in impaired functional integrity. The slope of the III-V/I-III interval ratio-rate function for the infants with bronchopulmonary dysplasia was also significantly steeper than those for the 2 control groups. Conclusions: The results suggest poor myelination and synaptic function of the brainstem in infants with bronchopulmonary dysplasia, resulting in impaired functional. To obtain an estimated neonatal risk that is not necessarily directly related to brainstem compromise, infants’ neonatal medical risk was assessed using the Clinical Risk Index for Babies (CRIB) ( CRIB and International Neonatal Network, 1993 ). Richards, Stefania Conte Edited by Jeffrey J. 043).Infants with longer IPI IV were more likely to have a deviant (17 words) receptive lexicon size (P.

Dynamic Epigenetic Impact of the Environment on the Developing Brain. Slower auditory processing (longer interpeak interval, IPI IV) in the right ear in the neonatal brainstem auditory evoked potential recording associated with smaller receptive lexicon size at 1 year (P. The slopes of the wave V latency-rate function and I-V and particularly III-V interval-rate functions for the infants with bronchopulmonary dysplasia were significantly steeper than those for both term and healthy, very preterm control subjects. The slope of the III-V/I-III interval ratio-rate function for the infants with bronchopulmonary dysplasia was also significantly steeper than those for the 2 control groups. Embodied Brain Model for Understanding Functional Neural Development of Fetuses and Infants. The wave I and III latencies and I-III interval in the infants with bronchopulmonary dysplasia did not show any abnormalities.

Compared with healthy, very preterm control subjects, all of these maximal length sequence brainstem auditory evoked response variables increased significantly at all click rates, although the differences between the 2 groups were slightly smaller than those between the infants with bronchopulmonary dysplasia and the term control subjects. All of these abnormalities became more significant as the click rate was increased. The III-V/I-III interval ratio also increased significantly at all click rates. Similarly, I-V and particularly III-V interpeak intervals increased significantly. Brainstem auditory evoked responses were recorded and analyzed by using the maximal length sequence technique.Ĭompared with term control subjects, wave V latency in the maximal length sequence brainstem auditory evoked response of the infants with bronchopulmonary dysplasia increased significantly at all 91 to 910 clicks per second rates. To gain new insights into the influence of bronchopulmonary dysplasia on the immature brain and to detect abnormalities, we studied the functional integrity of the brainstem in infants with bronchopulmonary dysplasia.įorty-one very preterm infants with bronchopulmonary dysplasia were studied at postconceptional ages of 37 to 42 weeks.

Lower brain stem function development in infants